Asymmetric Henry Reaction of 2-Acylpyridine N-Oxides Catalyzed by a Ni-Aminophenol Sulfonamide Complex: An Unexpected Mononuclear Catalyst

Asymmetric Henry Reaction of 2-Acylpyridine N-Oxides Catalyzed by a Ni-Aminophenol Sulfonamide Complex: An Unexpected Mononuclear Catalyst

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The asymmetric Henry reaction of 2-acylpyridine N-oxide ribavirin coupon remains a challenge as N-oxides generally act as competitive catalyst inhibitors or displace activating ligands.A novel variable yield (up to 99%) asymmetric Henry reaction of 2-acypyridine N-oxides catalyzed by a Ni-aminophenol sulfonamide complex with good to excellent enantioselectivity (up to 99%) has been developed.Mechanistic studies suggest that the unique properties of the electron-pairs of N-oxides for complexation with better waters xl7000 Ni makes the unexpected mononuclear complex, rather than the previously reported dinuclear complex, the active species.